Technology Readiness Level (TRL) Connections to Early Drug Discovery and Development (TRLs 1-3: Pre-Concept)

Previously we wrote about Biomedical and Line (non-medical) Department of Defense (DoD) Technology Readiness Levels (TRLs) and medical countermeasure (MCM) TRLs and discussed how a technology may develop through each TRL stage. Here, we will provide additional details on how biomedical TRLs apply specifically to early discovery and development (i.e., TRLs 1-3) drug, biologic or vaccine decision points for new chemical entities (NCE).

DoD biomedical-related technologies require TRL definitions ...

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DoD Technology Readiness Levels (TRLs) for Medical Countermeasures (MCMs)

We have introduced Biomedical and Line DoD Technology Readiness Levels (TRLs) and discussed how a technology may develop through each stage of the TRL scale for biomedical products such as medical devices. In this article, we will focus on how biomedical TRLs have been adapted for use with medical countermeasures (MCMs) and the unique requirements for development of MCM products, such as drugs and biologics.

Medical Countermeasures (MCMs)

Medical countermeasures (MCMs) are developed to prepare, protect ...

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Biomedical DoD Technology Readiness Levels (TRLs): Medical Devices

Previously, we briefly introduced Biomedical and Line DoD Technology Readiness Levels (TRLs) and discussed how a technology may develop through each stage of the TRL scale. Biomedical TRLs can be further categorized into TRLs for pharmaceuticals (drugs, biologics, and vaccines), medical devices, medical information management/information technology (IM/IT) and medical countermeasures (MCMs) following the FDA Guidance on Product Development under the Animal Rule. In this article, we will focus on biomedical DoD TRLs for medical devices.

Classification: Drug ...

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U.S. Navy Biomedical and Human Systems Communities of Interest (COI)

The Department of Defense (DoD) and other military assisting Federal Agencies have a large and diverse community of subject matter experts (SME) who are eager to collaborate with industry and universities. These extraordinary SMEs are driven to accelerate new and novel dual-use technologies forward to clinical and operational settings. There are thousands of healthcare providers in 167 DoD medical treatment facilities within the U.S. (59 Navy MTFs); tens of thousands of researchers in the

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Biomedical and Line DoD Technology Readiness Levels (TRLs)

Technology readiness assessments (TRA) are widely utilized by the U.S. Department of Defense (DoD) to determine a technology’s readiness for use in acquisition programs and projects (see the U.S. Government Accountability Office’s Technology Readiness Assessment Guide). The TRA frequently uses a maturity scale – technology readiness levels (TRLs) – that are ordered according to the characteristics of the demonstration or testing environment under which a given technology was tested at defined points in time. ...

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Cancer R&D Funding from the Congressionally Directed Medical Research Program (CDMRP)

Does your company have a therapeutic candidate (small molecule, monoclonal antibody, combination product, or other) for the treatment of a type of cancer? Does your therapeutic candidate have multiple indications for multiple types of cancers (e.g., drugs targeting reactive oxygen species [ROS] or cell surface receptors [GPCRs, EGFR]; protein inhibitors [Hsp90, ATR kinase]; epigenetic enzymes [LSD1]; or combination therapies [erlotinib ...

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